GELASTIC EPILEPSY PDF

A gelastic seizure, also known as “gelastic epilepsy”, is a rare type of seizure that involves a sudden burst of energy, usually in the form of laughing or crying. Information regarding gelastic epilepsy, a rare form of epilepsy that involves laughter or crying and is more common in boys than girls. What is Gelastic Epilepsy? Gelastic epilepsy refers to a type of epilepsy in which the seizures are ‘gelastic’, gelastikos being the Greek word for laughter.

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The horizontal diameter of the hypothalamic hamartoma was also measured laterally from the centre of the third ventricle and extended on average 0.

Gelastic seizure

For this reason some authors advised the surgical approach for patients with intractable epilepsy and severe behavior abnormalities. For instance, in a study of MRIs obtained from patients with hypothalamic hamartomas, Debeneix and colleagues compared the anatomical features of the lesions in patients with isolated precocious puberty nine patientsto patients with a combination of precocious puberty and seizures five patientsor with isolated felastic four subjects.

This can be done with different procedures including surgery and nonsurgical treatments such as radiosurgery Cascino et al GS are epileptic events characterized by bouts of laughter Gascon and Lombroso Posterior hypothalamic hamartomas and gangliomas causing precocious puberty. Endoscopic resection of hypothalamic hamartoma for refractory epilepsy: The association between central precocious puberty and GS was first described in a child who had a hypothalamic tumor attached to the belastic cinereum and mamillary bodies Dott Gellastic is important to note that our cohort included patients with hypothalamic hamartomas who had been referred to our Institute for the treatment of seizures and thus did not include any cases of hypothalamic hamartomas without seizures.

Taking into account slice thickness and interslice distance in each case, we visualized the distribution of the lesion locations using the mammillary level as the point of reference. It is a low risk option due to its lower frequency of neurological deficits. Harvey and colleagues report the seizure outcome of 29 patients with a mean follow up of epioepsy months using this approach. However, in patients with gelastic epilepsy-plus, we found a significantly older age and longer duration of disease measured in our cohort as the time lag between the onset of seizures and the time of preoperative neuroimaging.

Treatment options for gelastic epilepsy due to hypothalamic hamartoma: We believe future studies of hypothalamic hamartomas may reveal the gelastkc of nuclei that are at epilspsy core of seizure propagation from hypothalamic hamartomas to the other brain structures.

Gelastic Epilepsy: Signs and Information – Disabled World

These signs can include eye and head moving to one or the other side, automatisms such as lip-smacking, mumbling or fidgeting of the hands and altered awareness. Intellectual functioning in presurgical patients with hypothalamic hamartoma and refractory epilepsy. Ann Indian Acad Neurol ; It is rare for anyone to have their seizures controlled for more than a few weeks or months at a yelastic.

GS are almost always the first seizure manifestation of HH. These structures ge,astic be detected with different imaging modalities such as computed tomography and magnetic resonance imaging. Thus knowing the epilesy anatomical location of the usually well-defined single lesions in patients with hypothalamic hamartomas and gelastic epilepsy will help us generate hypotheses about the possible involvement of specific hypothalamic nuclei and neuroanatomical routes of seizure propagation in these cases.

Cases have also been described where that antiepileptic drugs have stopped seizures fully. While the question of epileptogenesis is outside the scope of our study, we aim to address the second question by analysing the neuroanatomy of hypothalamic lesions in more detail. The findings supporting a cortical involvement related with cerebral dysgenesis are controversial Berkovic et aland the favorable results with HH surgery point to the possibility of seizure geladtic from the HH to the cortex.

Gelastic Epilepsy

Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Mirth, laughter and gelastic seizures. The majority of these tumours are benign which means that they may grow only very slowly and do not spread to other parts of the brain or body.

In each case, the number of slices was multiplied by the slice thickness and added to epilepsg total interslice distance to estimate the dimensions from the mammillary bodies level. Stereotactic radiofrequency thermocoagulation of the HH has been used as a minimally invasive surgical approach. If a epilepys who suffers from the seizures is hooked up to an electroencephalogramit will reveal interictal epileptic discharges.

Finally Regis and colleagues and other authors have suggested the use of gamma knife in patients with residual lesions after surgery.

Barajas et al The laughter is many times described as being, ’empty,’ or, ‘hollow,’ and not pleasant. Currently the most effective surgical approach is the trancallosal anterior interforniceal approach, however newer approaches including the endoscopic and other treatment such as radiosurgery and gamma knife have been used with success. Table 1 Studies using gamma knife to treat patients with gelastic seizures.

The surgical procedure that has shown the best seizure outcome is the transcallosal approach but other nonsurgical procedures such as radiosurgery are gaining popularity because of good results. This finding likely reflects the natural history of the disease consistent with the hypothesis that age, rather than the size of the lesion, is gelasgic major risk factor for worsening of seizures Berkovic et al.

Many of these patients also suffer from cognitive decline, neuropsychiatric comorbidities and precocious puberty.