As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.
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Topics Discussed in Myron Paper. It was noted as wetting time. Spectral scanning was done in the range between cm This indicates that the drug release process is first order in nature. The co-processed superdisintegrants were evaluated for their flow and compression properties in comparison with physical mixture of superdisintegrants.
Required quantity is from 2. All the ingredients except granular directly compressible excipient were passed through sieve separately.
With 20 years kgron rich industry experience, we have emerged as one of the trusted manufacturers of Acrycoat, Acrypol, Colorcoat, Kyrton, Acrysol, Acryflow and Acryprint. Showing of 2 extracted citations. Granulation procedure Tablet Dosage Form.
Formulation of a convenient dosage form for administration and achievement of better patient compliance are the two most important criteria in novel drug delivery system [ 1 ]. A blend of crospovidone and Kyron T in the ratio of 1: Mouth dissolving tablets of aceclofenac were prepared by wet granulation technique using KYRON T as superdisintegrant and menthol as subliming agent. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique Mukesh GohelMadhabhai M.
From This Paper Figures, tables, and topics from this paper. Gandhi Department of Pharmaceutics, S. One of the main objectives of the present study was to prepare co-processed superdisintegrants of crospovidone and Kyron T which avoids the problem of segregation of individual superdisintegrants.
The co-processed superdisintegrants were prepared by solvent evaporation method. In vitro dissolution studies on all the prepared metoclopramide hydrochloride melt-in-mouth tablets were performed in pH 6. Rapid disintegrating agent Elimination of lump formation Compatible with all therapeutic agents and excipients Imparts excellent strength to the tablets Elimination of the sticking problems to the dies and punch Improves bioavailability of the drug Uniformly mix with low dose tablets blend or formulations Smooth surface after storage Provide smooth cream-like mouth feel, so more suitable for ODT Suitable for both direct compression and wet granulation methods Cost effective White in color Directly compressible grade Dissolution improver Effective at very low concentration 0.
As seen from Table 4 and 5all the tablets subjected to uniformity of drug content revealed the tablets to contain metoclopramide hydrochloride equivalent to metoclopramide between Direct compression, co-processed superdisintegrants, solvent-evaporation, crospovidone, Kyron T, metoclopramide hydrochloride, wetting time. These are manufactured using high quality basic material which is procured from reliable vendors.
A quantity of powder equivalent to 10 mg of metoclopramide hydrochloride was extracted in pH 6.
Export Data and Price of kyron t | Zauba
The composition of tablet is presented in Table 2. The simple physical blends and co-processed mixture of superdisintegrants were characterized for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and compatibility studies by FTIR spectroscopy.
Skip to search form Skip to main content. All the tablet formulations were evaluated for flow property and compression characteristics.
Evaluation of KYRON T-314 ( Polacrillin Potassium ) as a novel super disintegrant
Related Items Author’s work. It was observed that the tablets with shortest wetting time showed minimum disintegration time. About The Authors B.
The authors thank the Lincoln Pharmaceuticals Limited, Ahmedabad for providing gift samples of metoclopramide hydrochloride, crospovidone, polyvinylpyrrolidone and mannitol. The wet coherent mass was granulated through sieve. References Publications referenced by this paper. Powder was poured through the funnel until the apex of the conical pile touched the tip of the funnel.
Table 1 shows the parameters associated with flow of physical blend and co-processed mixture of crospovidone and Kyron T At intervals of 1 month, the tablets were visually examined for any physical changes and evaluated for in vitro drug release studies [ 16 ].
Email the author Login required. Call Send a quick kyroon. The prepared tablets were evaluated for physical parameters such as hardness, thickness, diameter, friability, weight variation, in vitro dispersion time, in vitro disintegration time, wetting time and water absorption ratio.
It is a very high purity polymer used in pharmaceutical formulations as a super fast disintegrant as well as dissolution improver in solid dosage forms like tablets, capsules, pellets etc.
The punches and die were lubricated with a small amount of magnesium stearate using a cotton swab preceding compression. Undoubtedly, all the formulations showed very short disintegration time, apart from oyron all compendial and other standard specifications, and exhibited faster release rates of metoclopramide hydrochloride. Subscribe to khron Newsletter All our latest content delivered to your inbox. Storage Store in tightly closed container. Store in tightly closed container.
Kyron T – View Specifications & Details by Corel Pharma Chem, Ahmedabad | ID:
For the measurement of angle of repose, a glass funnel was secured with its tip at a given height h above a piece of graph paper placed on a horizontal surface. Keep away from moisture. The reasons for selection of crospovidone are high capillary activity, pronounced hydration capacity and little tendency to form gels.
Among the tablets evaluated, formulation F-X prepared by adding co-processed superdisintegrants in ratio of 1: